<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:0479174d-27ec-4d31-89ab-a8752e111c63,g:3cdeef23-be33-4cf6-89e0-4c507639cea2-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.veracyte.com/role/CoverPage" xlink:type="simple" xlink:href="vcyt-20230608.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.veracyte.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_46ec1fdf-33e7-4d9c-86d0-7abe397a0440" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_DocumentType_46ec1fdf-33e7-4d9c-86d0-7abe397a0440" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_ce61f39b-391b-4e7c-80ab-ca803573fa73" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_DocumentPeriodEndDate_ce61f39b-391b-4e7c-80ab-ca803573fa73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_ff10ecf6-829f-45e5-abe1-c2a4e5e9b0e8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityRegistrantName_ff10ecf6-829f-45e5-abe1-c2a4e5e9b0e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_5ab4703b-8df2-4252-a313-b05f000a7b2d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityIncorporationStateCountryCode_5ab4703b-8df2-4252-a313-b05f000a7b2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_dffe85ec-430e-471b-835c-3f8d52b0530a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityFileNumber_dffe85ec-430e-471b-835c-3f8d52b0530a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_99784f3f-3fb4-4283-a391-634f37502a34" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityTaxIdentificationNumber_99784f3f-3fb4-4283-a391-634f37502a34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_3107b38b-29aa-4564-9e6e-5c10fd1fb6f6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityAddressAddressLine1_3107b38b-29aa-4564-9e6e-5c10fd1fb6f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_817c66c2-e68b-4d61-a2bd-8ba89b057a6b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityAddressAddressLine2_817c66c2-e68b-4d61-a2bd-8ba89b057a6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_fab46b9d-e0d0-4f12-8f2f-940e76af6025" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityAddressCityOrTown_fab46b9d-e0d0-4f12-8f2f-940e76af6025" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_564e5353-0f78-4ade-a9bb-8824afdac1b8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityAddressStateOrProvince_564e5353-0f78-4ade-a9bb-8824afdac1b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_bef63b7f-8e9d-46c1-856c-20d42eb55203" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityAddressPostalZipCode_bef63b7f-8e9d-46c1-856c-20d42eb55203" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d67f8879-ae37-445d-8284-0a6a4d681abf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_CityAreaCode_d67f8879-ae37-445d-8284-0a6a4d681abf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_1773aef7-9cce-4904-b030-96b9de086de4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_LocalPhoneNumber_1773aef7-9cce-4904-b030-96b9de086de4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_7750dba0-e8eb-44f7-b8ca-acbf485194be" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_WrittenCommunications_7750dba0-e8eb-44f7-b8ca-acbf485194be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_e3090abf-e1a1-4ab4-be53-c87ace018772" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_SolicitingMaterial_e3090abf-e1a1-4ab4-be53-c87ace018772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_d48608c4-6b9d-47e1-850d-4f62ecd149f5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_PreCommencementTenderOffer_d48608c4-6b9d-47e1-850d-4f62ecd149f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_323e2b80-5b2b-4acf-85e2-b229c81f0a37" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_323e2b80-5b2b-4acf-85e2-b229c81f0a37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_7e19db88-fb08-4b85-a45f-ff66477d53c4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_Security12bTitle_7e19db88-fb08-4b85-a45f-ff66477d53c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_4f968316-fab0-4cce-979c-9ae02c788fb6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_TradingSymbol_4f968316-fab0-4cce-979c-9ae02c788fb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_f8328f8b-7e9b-4092-9c19-3d89a255059a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_SecurityExchangeName_f8328f8b-7e9b-4092-9c19-3d89a255059a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_79cfe876-0499-4759-a0de-150eb7b1d4b3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityEmergingGrowthCompany_79cfe876-0499-4759-a0de-150eb7b1d4b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_d03f8a93-5d64-469a-a22f-f4cbcc69058b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_AmendmentFlag_d03f8a93-5d64-469a-a22f-f4cbcc69058b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_52b77fd7-766e-4b1b-ad76-92651046b9dd" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_EntityCentralIndexKey_52b77fd7-766e-4b1b-ad76-92651046b9dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_ab5445b3-91d5-4b02-bbf9-6915445fed5a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_315c934c-e8ae-49e8-a3a9-d9ad549b0c86" xlink:to="loc_dei_CurrentFiscalYearEndDate_ab5445b3-91d5-4b02-bbf9-6915445fed5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
