<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:1019f3f4-6295-46ed-9c36-a5287cf23c09,g:a708f7ee-7e4d-4532-b29b-a78fe95206c2-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.veracyte.com/role/CoverPage" xlink:type="simple" xlink:href="vcyt-20200605.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.veracyte.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_9d6265b0-0de6-49a7-baf0-282da36a2092" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_DocumentType_9d6265b0-0de6-49a7-baf0-282da36a2092" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_f25fa2fb-cb5f-4ea3-8e34-605f08909c36" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_DocumentPeriodEndDate_f25fa2fb-cb5f-4ea3-8e34-605f08909c36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_00e44662-d67e-4e68-980d-2355bf3c7a3e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityRegistrantName_00e44662-d67e-4e68-980d-2355bf3c7a3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_450357c5-23d3-4ce0-bac5-f31b7b9556de" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityIncorporationStateCountryCode_450357c5-23d3-4ce0-bac5-f31b7b9556de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_d9742cd7-dc96-46f7-8d66-45b783b28df1" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityFileNumber_d9742cd7-dc96-46f7-8d66-45b783b28df1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_63af5ce4-4fb3-49c7-ba5c-fdaa5e947e5b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityTaxIdentificationNumber_63af5ce4-4fb3-49c7-ba5c-fdaa5e947e5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_26b85617-0cfa-43af-9008-4767266aea39" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityAddressAddressLine1_26b85617-0cfa-43af-9008-4767266aea39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_072d912f-1ea5-45f6-b522-f78053f38eac" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityAddressAddressLine2_072d912f-1ea5-45f6-b522-f78053f38eac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_b133bde2-b23e-411a-94c9-8d93efc2c1fa" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityAddressCityOrTown_b133bde2-b23e-411a-94c9-8d93efc2c1fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_c5703097-b945-4e2f-be6f-f833ab73a07c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityAddressStateOrProvince_c5703097-b945-4e2f-be6f-f833ab73a07c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_cbb43525-b7d7-4703-9fe7-8632d4918c40" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityAddressPostalZipCode_cbb43525-b7d7-4703-9fe7-8632d4918c40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_69ba1f67-c53f-4631-a1c9-bd5115ac477e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_CityAreaCode_69ba1f67-c53f-4631-a1c9-bd5115ac477e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_9fa828c3-3c01-4376-9f16-1b328f11420b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_LocalPhoneNumber_9fa828c3-3c01-4376-9f16-1b328f11420b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_11373fa8-3595-4a71-9fb5-573df2137a4a" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_WrittenCommunications_11373fa8-3595-4a71-9fb5-573df2137a4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_3fe51bae-271e-4fbf-b147-2a4b13c8711b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_SolicitingMaterial_3fe51bae-271e-4fbf-b147-2a4b13c8711b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_ea2b9a92-e0cf-4a82-a1fc-322582685bd2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_PreCommencementTenderOffer_ea2b9a92-e0cf-4a82-a1fc-322582685bd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_b0c81aa6-1064-44fd-8a74-2e174aaf5afa" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_b0c81aa6-1064-44fd-8a74-2e174aaf5afa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_2f446e5a-049a-470d-b783-0128bc2bb8a7" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_Security12bTitle_2f446e5a-049a-470d-b783-0128bc2bb8a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_4d5d0fb6-e93e-4463-bb60-25781182b41a" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_TradingSymbol_4d5d0fb6-e93e-4463-bb60-25781182b41a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_d5f5e583-dc02-40f6-941b-eb1561d1743d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_SecurityExchangeName_d5f5e583-dc02-40f6-941b-eb1561d1743d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_4c809f34-f825-4055-bc6a-076ca7ed5a44" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityEmergingGrowthCompany_4c809f34-f825-4055-bc6a-076ca7ed5a44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_1ebf1916-5187-4a7b-a459-a9594a22507d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_AmendmentFlag_1ebf1916-5187-4a7b-a459-a9594a22507d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_6142b702-ef7b-479d-beae-f72180f534dd" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_EntityCentralIndexKey_6142b702-ef7b-479d-beae-f72180f534dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_7bc17fb1-10d2-4fdf-9bcc-aa5252c565b6" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4bb81d41-6785-4c05-ae50-242236770c24" xlink:to="loc_dei_CurrentFiscalYearEndDate_7bc17fb1-10d2-4fdf-9bcc-aa5252c565b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
