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  <xsd:element id="vcyt_RevenueRecognizedReceivedInCashPercentage" name="RevenueRecognizedReceivedInCashPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_RevenueRemainingPerformanceObligationAmountPerQuarter" name="RevenueRemainingPerformanceObligationAmountPerQuarter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="vcyt_SalesRevenueGrossMember" name="SalesRevenueGrossMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ScheduleOfCommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" name="ScheduleOfCommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ScheduleOfRevenueRecognitionCashAndAccrualBasisTableTextBlock" name="ScheduleOfRevenueRecognitionCashAndAccrualBasisTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_ServicesAgreementAbstract" name="ServicesAgreementAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardExpirationPeriodAfterTermination" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardExpirationPeriodAfterTermination" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumValueOfSharesPerEmployee" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumValueOfSharesPerEmployee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRollForward" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodMaximum" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriodMaximum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAnnualGrants" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAnnualGrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsInitialGrants" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsInitialGrants" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualLifeAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualLifeAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfVotingPowerOfAllClassesOfStock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfVotingPowerOfAllClassesOfStock" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodForWhichDirectorHasToServeAsBoardOfDirectorToReceiveGrantToPurchaseShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodForWhichDirectorHasToServeAsBoardOfDirectorToReceiveGrantToPurchaseShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermOfOptionsGrantedToEmployeesWhoOwnedSpecifiedPercentageOfClassOfStock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardTermOfOptionsGrantedToEmployeesWhoOwnedSpecifiedPercentageOfClassOfStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentageYearOne" name="SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentageYearOne" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfStockPercentageForGrantsToPersonsWhoOwnedSpecifiedPercentageOfClassOfStock" name="SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfStockPercentageForGrantsToPersonsWhoOwnedSpecifiedPercentageOfClassOfStock" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsVestedNumberofSharesTaxPortion" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsVestedNumberofSharesTaxPortion" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsandNonOptionEquityInstrumentsExercisesinPeriod" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsandNonOptionEquityInstrumentsExercisesinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_SharebasedCompensationArrangementbySharebasedPaymentAwardValueOptionsandNonOptionEquityInstrumentsExercisesinPeriod" name="SharebasedCompensationArrangementbySharebasedPaymentAwardValueOptionsandNonOptionEquityInstrumentsExercisesinPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_SiliconValleyBankMember" name="SiliconValleyBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_StockIncentivePlan2013Member" name="StockIncentivePlan2013Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_StockIssuedAndSoldDuringPeriodSharesInPrivatePlacement" name="StockIssuedAndSoldDuringPeriodSharesInPrivatePlacement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_StockIssuedAndSoldDuringPeriodValueInPrivatePlacement" name="StockIssuedAndSoldDuringPeriodValueInPrivatePlacement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_StockPlan2008Member" name="StockPlan2008Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetProvisionalIncomeTaxExpense" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetProvisionalIncomeTaxExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="vcyt_TermContractAgreement" name="TermContractAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_TermOfDebtWithEqualQuarterlyInstallments" name="TermOfDebtWithEqualQuarterlyInstallments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_TestingAndEvaluationServicesExpense" name="TestingAndEvaluationServicesExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_UnitedHealthcareMember" name="UnitedHealthcareMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="vcyt_VisiumMember" name="VisiumMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="vcyt_VotingRightsForEachShareOfStock" name="VotingRightsForEachShareOfStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
</xsd:schema>
