<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:21f84578-0bd4-4aab-99ed-5fa60607e7e1,g:4cf9fa26-92de-442c-8220-bad66e6397d4-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.veracyte.com/role/CoverPage" xlink:type="simple" xlink:href="vcyt-20220809.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.veracyte.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_cd8e34be-aaf6-4e2b-a7b6-0c3706c9f6d1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_DocumentType_cd8e34be-aaf6-4e2b-a7b6-0c3706c9f6d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_654b89bc-108b-43ce-b301-4e42c619f2c2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_DocumentPeriodEndDate_654b89bc-108b-43ce-b301-4e42c619f2c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_96294e9e-b631-40fd-b878-1ba21f7b7507" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityRegistrantName_96294e9e-b631-40fd-b878-1ba21f7b7507" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_37a6b706-ff45-4288-9e6e-f1301ae91bbc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityIncorporationStateCountryCode_37a6b706-ff45-4288-9e6e-f1301ae91bbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_6436e6ea-a022-4ac2-aa65-5d53d209f10e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityFileNumber_6436e6ea-a022-4ac2-aa65-5d53d209f10e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_af3fcb0b-1953-453d-b923-e2da071ecc04" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityTaxIdentificationNumber_af3fcb0b-1953-453d-b923-e2da071ecc04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_2c2f95eb-64b0-4164-be16-2c62dc8d7f60" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityAddressAddressLine1_2c2f95eb-64b0-4164-be16-2c62dc8d7f60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_cfa510e1-b755-4b69-830a-1f44208a2ab0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityAddressAddressLine2_cfa510e1-b755-4b69-830a-1f44208a2ab0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_0949fe14-8d7e-4bf8-84fb-8ab644675a66" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityAddressCityOrTown_0949fe14-8d7e-4bf8-84fb-8ab644675a66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_4412c3bb-20c4-4b17-9bae-72a79c7a0de4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityAddressStateOrProvince_4412c3bb-20c4-4b17-9bae-72a79c7a0de4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_5ed3b758-36fe-4cac-98d5-fde8346cdbd2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityAddressPostalZipCode_5ed3b758-36fe-4cac-98d5-fde8346cdbd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_0003b46c-5be4-4bdb-9eb5-504f32eb1f11" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_CityAreaCode_0003b46c-5be4-4bdb-9eb5-504f32eb1f11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_7f018e9d-50ab-4077-8e33-0b110b7093c1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_LocalPhoneNumber_7f018e9d-50ab-4077-8e33-0b110b7093c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_82e41343-600b-4924-8b4c-a7d10527e130" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_WrittenCommunications_82e41343-600b-4924-8b4c-a7d10527e130" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_38ddcbbc-0d78-4261-9807-126238a739e8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_SolicitingMaterial_38ddcbbc-0d78-4261-9807-126238a739e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_d9ba5f55-e7bc-473e-b940-b41450a8c090" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_PreCommencementTenderOffer_d9ba5f55-e7bc-473e-b940-b41450a8c090" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e3c57ea9-6403-411c-8f90-bcccaadf83f4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e3c57ea9-6403-411c-8f90-bcccaadf83f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_3a579421-baa9-4e50-8a36-cf8e19fa3b62" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_Security12bTitle_3a579421-baa9-4e50-8a36-cf8e19fa3b62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_83664857-41c2-40b2-9d76-afa84c453381" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_TradingSymbol_83664857-41c2-40b2-9d76-afa84c453381" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_82293397-bd9d-4f1c-b9f8-33eca15e680e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_SecurityExchangeName_82293397-bd9d-4f1c-b9f8-33eca15e680e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_9f808754-e885-4c33-ad49-f6b73ca297c2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityEmergingGrowthCompany_9f808754-e885-4c33-ad49-f6b73ca297c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_be22eebb-c062-4403-8865-b42a2d9a5a6b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_AmendmentFlag_be22eebb-c062-4403-8865-b42a2d9a5a6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_c248f79b-c4aa-4f60-86a1-65686cb1c82f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_2ee51dd5-8a4b-4ecb-b970-4d8114469069" xlink:to="loc_dei_EntityCentralIndexKey_c248f79b-c4aa-4f60-86a1-65686cb1c82f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
